Novel drug delivery strategies and gene therapy regimen as a promising perspective for management of psoriasis
نویسندگان
چکیده
Psoriasis is an autoimmune disorder; however, exact underlying mechanism responsible for psoriasis yet not known. A hypothesis put forward abnormal proliferation of keratinocytes due to faulty signals brought about by T-cells. Due the lack evidence cause, a variety treatments have been used which topical therapy usually first option in most patients. Topical has several shortcomings and barriers drug delivary may be effectively overcome using novel carrier systems exhibit maximum penetration, controlled release, reduced irritancy and, overall, better efficacy. Thus, treatment strategies based on gene such as antisensing nucleotide, silencing RNA complex, stem cell antibody-based are being envisaged. This review article discusses concepts background current delivery tools effective management psoriasis.
منابع مشابه
assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
چکیده ندارد.
15 صفحه اولProgress in Psoriasis Therapy via Novel Drug Delivery Systems
Psoriasis is a lifelong condition which is caused by the negative signals produced by immune system, which leads to hyper proliferation and other inflammatory reactions on the skin. In this case, keratinocytes which are the outermost layer of skin possess shortened life cycle and results in the alteration of desquamation process where the cytokines will come out through lesions of affected pati...
متن کاملProtein-based nanocarriers as promising drug and gene delivery systems.
Among the available potential colloidal drug carrier systems, protein-based nanocarriers are particularly interesting. Meeting requirements such as low cytotoxicity, abundant renewable sources, high drug binding capacity and significant uptake into the targeted cells, protein-based nanocarriers represent promising candidates for efficient drug and gene delivery. Moreover, the unique protein str...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Dermatology, Venereology and Leprology
سال: 2021
ISSN: ['0378-6323', '0973-3922']
DOI: https://doi.org/10.25259/ijdvl_470_19