Novel drug delivery strategies and gene therapy regimen as a promising perspective for management of psoriasis

نویسندگان

چکیده

Psoriasis is an autoimmune disorder; however, exact underlying mechanism responsible for psoriasis yet not known. A hypothesis put forward abnormal proliferation of keratinocytes due to faulty signals brought about by T-cells. Due the lack evidence cause, a variety treatments have been used which topical therapy usually first option in most patients. Topical has several shortcomings and barriers drug delivary may be effectively overcome using novel carrier systems exhibit maximum penetration, controlled release, reduced irritancy and, overall, better efficacy. Thus, treatment strategies based on gene such as antisensing nucleotide, silencing RNA complex, stem cell antibody-based are being envisaged. This review article discusses concepts background current delivery tools effective management psoriasis.

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ژورنال

عنوان ژورنال: Indian Journal of Dermatology, Venereology and Leprology

سال: 2021

ISSN: ['0378-6323', '0973-3922']

DOI: https://doi.org/10.25259/ijdvl_470_19